Hidden hysteresis 1 population dynamics can obscure gene network
نویسنده
چکیده
منابع مشابه
Hidden hysteresis – population dynamics can obscure gene network dynamics
BACKGROUND Positive feedback is a common motif in gene regulatory networks. It can be used in synthetic networks as an amplifier to increase the level of gene expression, as well as a nonlinear module to create bistable gene networks that display hysteresis in response to a given stimulus. Using a synthetic positive feedback-based tetracycline sensor in E. coli, we show that the population dyna...
متن کاملBistability and Tunable Gating in a Recurrent Neuronal Network with Synaptic Failure and Hidden Neurons
We study networks of all-to-all coupled, integrate-and-fire, excitatory neurons, with a portion of the population receiving feedforward drive and the remaining, " hidden " , portion receiving no feedforward input. We demonstrate that this system undergoes a subcritical bifurcation as either the input or recurrent coupling is varied. Because of this transition, the network gates feedforward inpu...
متن کاملDynamical state of the network determines the 1 efficacy of single neuron properties in shaping the 2 network activity
9 Spike patterns are among the most common electrophysiological descriptors of neuron types. Surprisingly, it is not clear how the diversity in firing patterns of the neurons in a network affects its activity dynamics. Here, we introduce the state-dependent stochastic bursting neuron model allowing for a change in its firing patterns independent of changes in its input-output firing rate relati...
متن کاملNeuronal Population Dynamics with Post Inhibitory Rebound: a Reduction to Piecewise Linear Discontinuous Circle Maps
Post inhibitory rebound is a nonlinear phenomenon present in a variety of nerve cells. It is an important mechanism underlying central pattern generation for heartbeat, swimming and other motor patterns in many neuronal systems. In this paper we propose an extension of the binary threshold neuron model to incorporate the eeects of post inhibitory rebound. For a single neuron, the dynamics can b...
متن کاملI-13: Transcriptome Dynamics of Human and Mouse Preimplantation Embryos Revealed by Single Cell RNA-Sequencing
Background: Mammalian preimplantation development is a complex process involving dramatic changes in the transcriptional architecture. However, it is still unclear about the crucial transcriptional network and key hub genes that regulate the proceeding of preimplantation embryos. Materials and Methods: Through single-cell RNAsequencing (RNA-seq) of both human and mouse preimplantation embryos, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2013